What Are The Different Types Of Testosterone Treatments? - Charles E. Boyk Law Offices, LLC

What Are The Different Types Of Testosterone Treatments?

What Are The Different Types Of Testosterone Treatments?

What Are The Different Types Of Testosterone Treatments?

How Is Hypogonadism Treated?

If a man has been diagnosed with androgen deficiency, he may be a candidate for testosterone therapy (TT).  It should be a therapeutic goal to raise his T levels to the low to mid range of the reference range (240-950 ng/dl)[i]. Pharmaceutical companies have developed and commercialized several types of TT for low T.  Following is a list of some of the most prevalent types of TT products in the U.S.:

Intramuscular Injection:   Until recently, injection therapy was one of the most frequently used treatment methods.  Injections, usually self-administered, are taken at periodic intervals of typically two weeks or more.  Available products include:

  • DEPO-Testosterone, which is manufactured by Pfizer; and
  • Delatestryl, which is manufactured by Endo Pharmaceuticals.

Transdermal/Topical:  Transdermal testosterone delivery includes daily gel applications and patches.  These products are far and away the most prescribed products.  They include:

  • Forestra, which is manufactured by Endo Pharmaceuticals.  Forestra is a gel that is applied once daily to the thighs in the morning.
  • AndroGel, is currently promoted by AbbVie, formerly part of Abbott Labs, and Actavis AndroGel is applied once daily in the mornings to the shoulders and upper arms.
  • Androderm, is manufactured by Actavis, formerly Watson Pharm.  Androderm is applied a patch product that is applied daily to the back, abdomen, upper arms, or thighs.
  • Axiron, is manufactured by Lilly.  It is a topical solution that is applied once daily, generally in the morning, to the underarms.
  • Testrim, is manufactured by Auxilium Pharmaceuticals.  It is a gel that is applied once daily to the shoulders and upper arms.

Buccal:  Buccal formulations of testosterone involve placing a product with a bioadhesive onto the gums where it delivers an extended dose of testosterone through the gums and cheeks.   Available products include:

  • Striant.  Striant is currently marketed by Auxilium in the U.S.  It is applied to the upper gum twice daily, approximately 12 hours apart.

Subdermal Implant:  Subdermal testosterone implants are surgically implanted underneath the skin.  They deliver prolonged, steady-doses of testosterone.  Products include:

  • Testopel.  Testopel is manufactured by Auxilium.  Is placed underneath the skin where it delivers 3-6 months of testosterone.

[i] J Clin Endocrinol Metab. 2007;92:3844–3853, “Androgen receptor gene CAG repeat length and body mass index modulate the safety of long-term intramuscular testosterone undecanoate therapy in hypogonadal men.”

Charles E. Boyk Law Offices, LLC